Glucokinase and the potential of glucokinase activation in type 2 diabetes
نویسندگان
چکیده
منابع مشابه
Targeting Hepatic Glucokinase in Type 2 Diabetes
Glucokinase (hexokinase IV) has a major role in the control of blood glucose homeostasis because it is the predominant hexokinase expressed in the liver, has a very high control strength on hepatic glucose disposal (1), and is the glucose sensor for insulin secretion in pancreatic -cells (2). Glucokinase is currently considered a strong candidate target for antihyperglycemic drugs for type 2 di...
متن کاملDecreased expression of hepatic glucokinase in type 2 diabetes
BACKGROUND/OBJECTIVES Increased endogenous glucose production is a hallmark of type 2 diabetes. Evidence from animal models has suggested that a likely cause of this is increased mRNA expression of glucose 6-phosphatase and phosphoenolpyruvate carboxykinase (encoded by G6PC, PCK1 and PCK2). But another contributing factor may be decreased liver glucokinase (encoded by GCK). METHODS We examine...
متن کاملThe network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy.
The glucose-phosphorylating enzyme glucokinase has structural, kinetic, and molecular genetic features that are ideal for its primary role as glucose sensor in a network of neuro/endocrine sentinel cells that maintain glucose homeostasis in many vertebrates including humans. The glucokinase-containing, insulin-producing beta-cells of the pancreas take the prominent lead in this network, functio...
متن کاملGlucokinase Activators for Diabetes Therapy
Type 2 diabetes is characterized by elevated blood glucose levels resulting from a pancreatic b-cell secretory insufficiency combined with insulin resistance, most significantly manifested in skeletal muscle and liver (1). If untreated, diabetic complications develop that cause loss of vision, peripheral neuropathy, impaired kidney function, heart disease, and stroke. The disease has a polygeni...
متن کاملTreatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein.
The enzyme glucokinase (GK) plays a central role in glucose homeostasis. Hepatic GK activity is acutely controlled by the action of the GK regulatory protein (GKRP). In vitro evidence suggests that GKRP reversibly binds to GK and inhibits its activity; however, less is known about the in vivo function of GKRP. To further explore the physiological role of GKRP in vivo, we used an E1/E2a/E3-defic...
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ژورنال
عنوان ژورنال: Journal of Diabetes
سال: 2019
ISSN: 1753-0393,1753-0407
DOI: 10.1111/1753-0407.12937